DALLAS REGENERATIVE SOLUTIONS
Technology for the Regenerative Revolution
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Regenerative Solution: Biologics
Mesenchymal Stem Cells
All Mesenchymal Stem Cell (MSC) biologics carried by Dallas Regenerative Solutions are obtained from donated, full-term, and live birth pregnancies. Donors go through a comprehensive screening process and are tested in accordance with standards established by FDA requirements to minimize risks of disease transmission to recipients.
Structural Wharton’s Jelly
Wharton’s jelly is a gelatinous substance in the umbilical cord that provides cushioning and support to the umbilical vein and arteries. The cushioning and protective elements from Wharton’s jelly consist of a network of structural proteins, pericytes, mesenchymal stem cells, cytokines, chemokines and growth factors. Hyaluronic acid is the most abundant component of the glycosamnioglycans found in the umbilical cord matrix. Hyaluronic acid is also a key factor in the viscoelastic properties in synovial fluid of joints.
"Cord blood" refers to blood from the umbilical cord and placenta. Usually, the cord is traditionally discarded after birth. Compared to bone marrow, cord blood cells are "immature", which means they haven’t been exposed to a disease. Stem cells in the umbilical cord are different from bone marrow stems cells, which have been the treatment standard for stem cell therapies. The cells in cord blood include hematopoietic progenitor cells (HPC) and hematopoietic stem cells (HSC), which are also found in bone marrow and peripheral blood.
What is an Allograft?
An allograft is tissue from a human donor that is transplanted from one body to another.
Why Human Amniotic Tissues?
Clinicians have used human amniotic tissues for over a century as a biologic dressing in a broad range of therapeutic applications. They have been generally recognized as versatile wound coverings, with published clinical results cited extensively in the literature. Human amniotic tissues are an abundant source of collagen, as well as other proteins and cytokines. Human amniotic tissues are "immuneprivileged" and therefore rarely cause an immune response in the human body. In addition, this tissue has been shown to have anti-inflammatory, anti-microbial and anti-adhesive properties. The collagens in the amniotic tissue provide a structural tissue matrix for cellular attachment. While providing structural support to cells, the extracellular matrix assists in the migration and proliferation of the patient’s own cells to the site of injury or defect.
The cells inherent in the human placental tissues have been found to be broadly multipotent, capable of differentiating into adipogenic, osteogenic, myogenic, endothelial, neurogenic and hepatic cell lineages. The presence of these multipotent cells naturally present in the tissues may provide ancillary clinical benefits to the patient.
Human Amniotic Tissue
Human amniotic tissue allografts processed using proprietary technologies have been shown clinically and scientifically to support soft tissue repair and can release growth factors up to 70-90 X a 5x Concentration PRP. These products are a minimally manipulated human tissue allograft derived from human tissues, and can include the extracellular matrix of the amniotic membrane. It is processed to preserve cytokines, growth factors and scaffolding proteins in amniotic membrane for homologous use.
Platelet Rich Plasma (PRP) / Platelet-rich Fibrin Matrix (PRFM) / Leukocyte-reduced PRP (LrPRP)
Platelet-rich plasma (PRP) is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to remove red blood cells. It has a greater concentration of growth factors than whole blood, and has been used to encourage a brisk healing response across several specialties, in particular plastic surgery, dentistry, orthopedics and dermatology. As a concentrated source of blood plasma and autologous conditioned plasma, PRP contains several different growth factors and other cytokines that can stimulate healing of soft tissue and joints.
Mesenchymal Stem Cell Exosomes
Exosomes are extracellular vesicles ranging between 30-150 nm that are produced by virtually every cell type as a means of intercellular communication They contain proteins (growth factors), mRNA (blueprint for protein production) and micro RNA (on a switch for specific protein production), all contained within a membrane similar to their parent cells that protects exosomal proteins and RNA from degradation until they are delivered to the target cell.
MSC exosomes are very different than exosomes found in adult bone marrow, which has a preponderance of hematopoietic stem cell exosomes, or amniotic fluid, which has primarily maternal epithelial cell exosomes. The distinct ability of MSC exosomes to induce connective tissue synthesis may be the basis of many of the remarkable clinical benefits that have been observed with stem cell therapy.
As we age, the number and function of the MSCs in our tissues declines sharply. Aged autologous progenitor cells produce about 30% of the cytokines and significantly different miRNAs compared with perinatal MSCs. This substantial difference in secretome confers a significant advantage of perinatal MSC exosomes over exosomes from aged autologous or allogeneic progenitor cells.
REGENERATIVE SOLUTION: DEVICES
Extracorporeal Shockwave Therapy (ECSWT) / (Low Intensity Shockwave Therapy (LiSWT)
Extracorporeal Shockwaves have been used successfully in Europe for over a decade for a variety of conditions, including heart disease, kidney stones and orthopedic conditions.
The technology works by accelerating a projectile in the hand piece which generates a mechanical pressure wave. This wave is transferred to the human body by an applicator head and which radiates out in the tissue. The mechanical energy is absorbed by the tissue and decreases as the distance from the application site increases. The mechanical stress causes cavitation resulting in reactions in the tissue.
The benefits of the therapy’s mechanical stimulation include: increased local blood flow, cellular activity such as the release of substance P, prostaglandin E2, NO, TGF β, VEGF, and almost certainly other inflammatory cytokines, the breakdown of calcific deposits and adhesions, and finally relaxation of connective tissue.
IR LL Laser Therapy
Low-level laser (light) therapy (LLLT) is a fast-growing technology used to treat a multitude of conditions that require stimulation of healing, relief of pain and inflammation, and restoration of function. The photons are absorbed by mitochondrial chromophores in skin cells. Consequently, electron transport, adenosine triphosphate (ATP) nitric oxide release, blood flow, reactive oxygen species increase and diverse signaling pathways get activated. Stem cells can be activated allowing increased
tissue repair and healing. In dermatology, LLLT has beneficial effects on wrinkles, acne scars, hypertrophic scars, and healing of burns. LLLT can reduce UV damage both as a treatment and as a prophylaxis. In pigmentary disorders such as vitiligo, LLLT can increase pigmentation by stimulating melanocyte proliferation and reduce depigmentation by inhibiting autoimmunity. Inflammatory diseases such as psoriasis and acne can also benefit.
This is a wounding laser, which removes thin layers of skin. Types of ablative treatments include the carbon dioxide (CO2) laser and the erbium laser.
This is a non-wounding laser, which stimulates collagen growth and tightens underlying skin. This includes many types of lasers as well as intense pulsed light (IPL) devices.
Another type of laser resurfacing, fractional photothermolysis (Fraxel), is available in ablative and non-ablative forms. Although non-ablative laser resurfacing is less invasive and requires less recovery time, it's less effective than is ablative laser resurfacing.
High Power Laser Therapy (HPLT) is now widely recognized as a safe, pain-free and non-invasive medical procedure to accelerate the treatment and rehabilitation of various acute and chronic pain conditions. HPLT devices are used in hundreds of medical facilities through the United States, including prestigious medical schools as well as the Department of Defense, the VA system, the NBA, NFL and MLB.
HPLT offers patients a painless, non-surgical and side effect free treatment for conditions previously refractive to traditional medical care. The mechanism of action for laser therapy comes from its ability, at the cellular level, to "bio-stimulate" tissue growth and repair.
Class IV High Powered Laser Therapy
This results in accelerated wound healing as well as a dramatic decrease in pain, inflammation and scar tissue formation. Unlike all other treatment modalities, laser therapy actually "heals" tissue, providing a powerful non-addictive form of pain management.
Additionally, multiple studies have shown that HPLT safely and effectively activates stem cells without any detrimental effect upon the stem cells whatsoever. Laser therapy causes stem cell activation at the target site of photonic stimulation, where stem cell proliferation has been shown to occur along with the maintenance of cellular viability. Laser therapy also enhances stem cell procedures by accelerating articular cartilage regeneration, pain reduction and reduction of bony edema just to name a few of the numerous synergies between the two procedures.
REGENERATIVE SOLUTION: CUSTOM COMPOUNDING
A compounding pharmacist can create customized treatment options for many health issues, including nutritional
support to help maintain health. Pharmacy compounding is the art and science of preparing customized medications for patients.
An important benefit is the compounding pharmacist’s ability to alter the delivery system of medications. Working closely with a healthcare provider, a compounding pharmacist can develop a dosage form that works best for the patient.
Many medications, such as some used to treat aches and pains, are commonly available as capsules or tablets. However, medications taken orally must pass through a patient’s digestive tract before making their way into the system, which may delay the effect of the medication or result in gastrointestinal side effects.
With a prescriber’s consent, a compounding pharmacist can prepare many of these medications as topical preparations – creams, lotions, solutions, or gels which are applied directly to the skin. Topical preparations allow the drug to be absorbed through the skin and enter the bloodstream, bypassing the gastrointestinal tract and potentially minimizing the related side effects. Some medications also may be formulated in dosage forms like flavored troches, which dissolve in the mouth and quickly enter the bloodstream.
Unique Dosage Forms
Modern technology and innovative techniques and research allow many healthcare providers to work with pharmacists to customize medications, which provide their patients with the benefit of medications tailored specifically for certain needs. A compounding pharmacist can tailor a prescription to the exact strength required by the individual patient and make it in a dosage form that is easy for the patient to use. This may allow the patient to comply better with the dosing instructions, resulting in a more positive experience and treatment outcome.
Acne Skin, Anesthetics (Laser and Non-laser procedures), Anti-Aging Formulas such as Collagen Boosters, Bleaching / Skin Lightening, Cheloids, Cleansers, Dry & Cracking Skin, Eczema, Facial Peels, Firming, Fungal Infections, Hair Loss / Balding, Hormone Therapy (Testosterone), Keratosis Pilaris, Masks, Moisturizers, Numbing, Pre-Peel, Post-Peel, Physical Exfoliants, Psoriasis, Radiation Burns, Rosacea, Scalp Solutions, Scalp Psoriasis, Seborrheic Dermatitis, Sexual Wellness (Erectile Dysfunction, Low Libido, Vaginal Dryness), Shaving Solutions, Shingles, Skin Renewal, Smoking Cessation, Under Eye, Vitiligo, Warts, Wounds, and More!
Compounds and Solutions Available for the Following and more!
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